What do they do?
Proanthocyanidins have antioxidant activity and they play a role in the stabilization of collagen and maintenance of elastin—two critical proteins in connective tissue that support organs, joints, blood vessels, and muscle.1 2 Possibly because of their effects on blood vessels, proanthocyanidins have been reported in double-blind research to reduce the duration of edema after face-lift surgery from 15.8 to 11.4 days.3 In preliminary research, proanthocyanidins were reported to have anti-mutagenic activity (i.e., to prevent chromosomal mutations).4
Proanthocyanidins have been shown to strengthen capillaries in double-blind research using as little as 100 mg per day.5 In another double-blind trial, French researchers reported that women with chronic venous insufficiency had reduced symptoms using 150 mg per day.6 In another French double-blind trial, supplementation with 100 mg taken three times per day, resulted in benefits within four weeks.7
Proanthocyanidins (200 mg per day for five weeks) have improved aspects of vision (visual performance in the dark and after exposure to glare) in healthy people.8 9 A product that is high in proanthocyanidins has been shown to prevent and reverse abnormal blood clotting in smokers.10
Where are they found?
Proanthocyanidins have been used in connection with the following conditions (refer to the individual health concern for complete information)
Who is likely to be deficient of grape seed?
How much grape seed is usually taken?
Are there any side effects or interactions with grape seed?
At the time of writing, there were no well-known drug interactions with Proanthocyanidins.